At long last....

H3K27 Demethylases, at Long Last

Methylation of lysine 27 on histone H3 (H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers (Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation o...

The end of a long search: at last thrombopoietin.

At most at last

Recent pragmatic accounts derive the ignorance inferences to which superlative modifiers give rise as quantity implicatures in a neo-Gricean framework. While these approaches successfully account for the interaction of at least with modals, the behavior of at most remains a puzzle. I propose that at most is composed of an antonymizing operator and at least and show how this accounts for the int...

At long last, long-lasting psychiatric medications: an overview of controlled-release technologies.

BRAINSTORMS is a monthly section of The Journal of Clinical Psychiatry aimed at providing updates of novel concepts emerging from the neurosciences that have relevance to the practicing psychiatrist. From the Neuroscience Education Institute in Carlsbad, Calif., and the Department of Psychiatry at the University of California San Diego. Reprint requests to: Stephen M. Stahl, M.D., Ph.D., Editor...

Free, at last!

Infectious diseases have moulded the development of the human species more than any other biological or abiological factor. They have influenced not only our biology, but also our history and political development; from the outcome of wars to the success of empires, and from the pace of technological advance to the structure of society itself. The introduction of smallpox to the Americas by Eur...